[Ru3O(CH3COO)6(4-pic)2(NO)]PF6

[Ru3O(CH3COO)6(4-pic)2(NO)]PF6 is a triruthenium nitrosyl cluster that acts as a photoactive pro-drug for the delivery of nitric oxide (NO). The complex consists of a triruthenium core coordinated by six acetate ligands, two 4-picoline (4-methylpyridine) ligands, and a nitrosyl group, with a hexafluorophosphate counterion. It is designed to release NO upon irradiation with visible light (e.g., λ = 532 nm) or through redox-mediated reactions in the cellular environment. In preclinical in vitro studies, the compound has demonstrated significant tumoricidal activity against B16F10 melanoma cells, reducing cell viability by up to 90% upon irradiation. The cytotoxicity is primarily attributed to the release of nitric oxide, which acts as the active species to induce cell death.

Other names

triruthenium nitrosyl clusternitrosyl cluster 1compound 1compound1compound-1